Acromus (Eye Ointment)
“PICKED FOR VERNAL KERATOCONJUNCTIVITIS”
- Tacrolimus is a non-steroidal immunosuppressant drug.
- Tacrolimus also known as FK 506 is a macrolide derivative with anti-inflammatory and immunomodulatory activity.
- It is very useful and potent drug for the treatment of vernal keratoconjuctivitis.
- It replaces steroid therapy which have many adverse effects.
- It is more potent than other drugs.
- Tacrolimus acts as anti-inflammatory and immunomodulatory.
- It suppress the T cell activation and interleukin-2 production by binding to an immunophilin and inhibiting the enzymatic activity of calcineurin
- Calcineurin is the protien phosphate depends on calcium and calmodulin
- Calcineurin activates T-cell and interleukin-2 which causes immunological problems.
- When tacrolimus prevent the activity of calcineurin automaticaly deactivation of helper T-cell and interleukins occur.
- It also inhibit release of histamine from mast cell which also cause allergic condition so after inhibition allergic conditions might stop.
- It is used as anti-inflammatory.
- Tacrolimus has shown to be effective in the treatment of immune-mediated diseases such as corneal graft rejection, ocular inflammation, ocular pemphigoid, and uveitis.
- Twice daily for 4 weeks followed by a 2 weeks washout period. Patients were followed up at the end of 1st week, 4th week, and at 7th week (2 weeks washout period).
- Gently pull down your lower eyelid and look up. Hold the tube above the eye and gently squeeze a 1cm line of ointment along the inside of the lower eyelid, taking care not to touch the eye or eyelashes with the tip of the tube. Blink your eyes to spread the ointment over the surface of the eyeball.
- Sunlight (UV) exposure
- Grapefruit juice
- Cold or flu symptoms such as stuffy nose, sneezing, sore throat;
- Red eyes and tearing during tacrolimus treatment
The only major adverse reactions are-
- Transient burning sensation upon drop instillation
- Corneal infections,
- Including bacterial keratitis,
- Herpetic keratitis and
- A bacterial corneal ulcer,
- Atopic dermatitis or asthma